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pentobarbital will lower the level or effect of tipranavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers raise price of toremifene metabolism, reducing the continuous-state conce